Lupus erythematosus
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چکیده
Definiton Lupus erythematosus (LE) is an autoimmune disorder, in which the body's own immune system attacks its own tissues, especially components of the cellular nuclei. Lupus is the latin for wolf and erythematosus indicates red-like. Thus, LE stands for ”the red wolf” which should be in contrast to lupus vulgaris, ”the common wolf” which in the old days designated the skin of the face in patients with cutaneous tuberculosis. There are two main forms of lupus, discoid LE (DLE), affecting skin and mucous membranes, and systemic LE (SLE), which may also affect joints, visceral organs and other tissues. The classification may now also include a bullous form, a neonatal form (NLE), an acute cutaneous form (ACLE), a subacute cutaneous form (SCLE) and a chronic cutaneous form (CCLE). There is also a special subgroup of SLE with very early onset, childhood-onset systemic lupus erythematosus, cSLE. In addition, there is probably a drug-induced, and thus potentially reversible form of LE.
منابع مشابه
Scalp sarcoidosis mimicking discoid lupus erythematosus with lichenoid features in histology
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Codon 72 Polymorphism of p53 Gene and Hematologic Manifestations in Patients with Systemic Lupus Erythematosus
Background: Systemic lupus erythematosus is a systemic autoimmune disorder with unclear etiology. The importance of some genes in the development of systemic lupus erythematosus has been implicated. The gene polymorphism in codon 72 has attracted a lot of attention and its role in the occurrence or progression of many cancers and autoimmune diseases especially systemic lupus erythematosus has ...
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